imatinib-loaded peg-modified magnetic nanoparticles as an anti-cancer agent for ph responsive targeted drug delivery

imatinib-loaded peg-modified magnetic nanoparticles as an anti-cancer agent for ph responsive targeted drug delivery

targeted drug delivery is a promising approach to overcome the limitations of classical chemotherapy. in this respect, imatinib-loaded peg-modified magnetic nanoparticles were prepared as a ph sensitive system for targeted delivery of drug to tumor sites by applying a magnetic field. the proposed magnetic nanoparticles were prepared through modification of magnetic fe₃o₄ nanoparticles with peg400 and then imatinib. the structural, morphological and physicochemical properties of the synthesized nanoparticles were determined by different analytical techniques including energy-dispersive x-ray spectroscopy (eds), field emission scanning electron microscopy (fe-sem), fourier-transform infrared (ftir) spectroscopy, transmission electron microscopy (tem), vibrating sample magnetometry (vsm),

and x-ray diffraction (xrd). uv/visible spectrophotometry was used to measure the imatinib contents. drug loading and release profile of the prepared particles was investigated. the results demonstrated that fe₃o₄@peg acts as a ph responsive nanocarrier in releasing the loaded imatinib molecules. furthermore, the fe₃o₄@peg/imatinib nanoparticles displayed cytotoxic effect against mcf-7 breast cancer cells.