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نویسندگان مقالات پربازدید :
مواد زیستی
جزئیات رویداد
همایش ، رویداد ، ژورنال
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  • indocyanine green-loaded biodegradable tumor targeting nanoprobes for in vitro and in vivo imaging

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    جزئیات بیشتر مقاله
    • تاریخ ارائه: 1391/01/01
    • تاریخ انتشار در تی پی بین: 1391/01/01
    • تعداد بازدید: 711
    • تعداد پرسش و پاسخ ها: 0
    • شماره تماس دبیرخانه رویداد: -
     indocyanine green (icg) is a near-infrared (nir) fluorescence dye for extensive biological application, but limited by its poor aqueous stability in vitro, concentration-dependent aggregation, rapid elimination from the body, and lack of target specificity. in this paper, to overcome these limitations, folate receptor-targeted, icg dye-doped poly(d,l-lactide-co-glycolide) (plga) lipid nanoparticles (fa-icg-plga-lipid nps) were constructed by a single-step self-assemble and nanoprecipitation method. the prepared fa-icg-plga-lipid nps exhibited good biocompatibility, monodispersity, excellent nir penetration ability, significant stability against photobleaching and long circulation time. the intracellular uptake experiment proved the targeting efficacy of the fa-icg-plga-lipid nps was more effective in folate receptor over-expressing mcf-7 cells than folate receptor negative a549 cells. furthermore, the in vivo experiments showed the fa-icg-plga-lipid nps were specifically targeted to the tumor, and its circulation time was much longer than free icg. these biocompatible and biodegradable nir-nps prove a potential application in tumor diagnosis and targeted imaging due to its high aqueous stability, excellent nir optical properties and significantly targeting property in vivo.

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