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آکتا بیومتریال
جزئیات رویداد
همایش ، رویداد ، ژورنال
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  • multifunctional polymeric microfibers with prolonged drug delivery and structural support capabilities

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    • تاریخ ارائه: 1392/01/01
    • تاریخ انتشار در تی پی بین: 1392/01/01
    • تعداد بازدید: 703
    • تعداد پرسش و پاسخ ها: 0
    • شماره تماس دبیرخانه رویداد: -
     the strength and stability of hybrid fiber delivery systems, ones that perform a mechanical function and simultaneously deliver drug, are critical in the design of surgically implantable constructs. we report the fabrication of drug-eluting microfibers where drug loading and processing conditions alone increase microfiber strength and stability partially due to solvent-induced crystallization. poly(l-lactic acid) microfibers of 64 ± 7 μm diameter were wet spun by phase inversion. encapsulation of a model hydrophobic anti-inflammatory drug, dexamethasone, at high loading provided stability to microfibers which maintained linear cumulative release kinetics up to 8 weeks in vitro. in our wet spinning process, all microfibers had increased crystallinity (13–17%) in comparison to unprocessed polymer without any mechanical stretching. moreover, microfibers with the highest drug loading retained 97% of initial tensile strength and were statistically stronger than all other microfiber formulations, including control fibers without drug. results indicate that the encapsulation of small hydrophobic molecules (<400 da) may increase the mechanical integrity of microfilaments whose crystallinity is also increased as a result of the process. multifunctional drug-eluting microfibers can provide an exciting new opportunity to design novel biomaterials with mechanical stability and controlled release of a variety of therapeutics with micron-scale accuracy.

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