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نویسندگان مقالات پربازدید :
آکتا بیومتریال
جزئیات رویداد
همایش ، رویداد ، ژورنال
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  • the effect of an octacalcium phosphate co-precipitated gelatin composite on the repair of critical-sized rat calvarial defects

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    • تاریخ ارائه: 1392/01/01
    • تاریخ انتشار در تی پی بین: 1392/01/01
    • تعداد بازدید: 737
    • تعداد پرسش و پاسخ ها: 0
    • شماره تماس دبیرخانه رویداد: -
     this study was designed to investigate the extent to which an octacalcium phosphate/gelatin (ocp/gel) composite can repair rat calvarial critical-sized defects (csd). ocp crystals were grown with various concentrations of gelatin molecules and the ocp/gel composites were characterized by chemical analysis, x-ray diffraction (xrd), fourier transform infrared (ftir) spectroscopy, transmission electron microscopy (tem), selected area electron diffraction (saed) and mercury intrusion porosimetry. the ocp/gel composite disks received vacuum dehydrothermal treatment, were implanted in wistar rat calvarial csd for 4, 8 and 16 weeks, and then subjected to radiologic, histologic, histomorphometric and histochemical assessment. the attachment of mouse bone marrow stromal st-2 cells on the disks of the ocp/gel composites was also examined after 1 day of incubation. ocp/gel composites containing 24 wt.%, 31 wt.% and 40 wt.% of ocp and with approximate pore sizes of 10–500 μm were obtained. plate-like crystals were observed closely associated with the gel matrices. tem, xrd, ftir and saed confirmed that the plate-like crystals were identical to those of the ocp phase, but contained a small amount of sphere-like amorphous material adjacent to the ocp crystals. the ocp (40 wt.%)/gel composite repaired 71% of the csd in conjunction with material degradation by osteoclastic cells, which reduced the percentage of the remaining implant to less than 3% within 16 weeks. of the seeded st-2 cells, 60–70% were able to migrate and attach to the ocp/gel composites after 1 day of incubation, regardless of the ocp content. these results indicate that an ocp/gel composite can repair rat calvarial csd very efficiently and has favorable biodegradation characteristics. therefore, it is hypothesized that host osteoblastic cells can easily migrate into an ocp/gel composite.

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