in vivo porcine left atrial wall stress: computational model

most computational models of the heart have so far concentrated on the study of the left ventricle, mainly using simplified geometries. the same approach cannot be adopted to model the left atrium, whose irregular shape does not allow morphological simplifications. in addition, the deformation of the left atrium during the cardiac cycle strongly depends on the interaction with its surrounding structures. we present a procedure to generate a comprehensive computational model of the left atrium, including physiological loads (blood pressure), boundary conditions (pericardium, pulmonary veins and mitral valve annulus movement) and mechanical properties based on planar biaxial experiments. the model was able to accurately reproduce the in vivo dynamics of the left atrium during the passive portion of the cardiac cycle. a shift in time between the peak pressure and the maximum displacement of the mitral valve annulus allows the appendage to inflate and bend towards the ventricle before the pulling effect associated with the ventricle contraction takes place. the ventricular systole creates room for further expansion of the appendage, which gets in close contact with the pericardium. the temporal evolution of the volume in the atrial cavity as predicted by the finite element simulation matches the volume changes obtained from ct scans. the stress field computed at each time point shows remarkable spatial heterogeneity. in particular, high stress concentration occurs along the appendage rim and in the region surrounding the pulmonary veins.