synthesis and characterization of fe3o4 coated on apts as carriers for theophylline drug

theophylline is a drug anti-asthma. fe₃o₄ magnetic nanoparticles (mnps) coated on 3-aminopropyl triethoxysilane (aptes) were synthesized (mnps-aptes) as carriers for theophylline. the characterization of drug delivery system was confirmed by fourier transform infrared (ftir), scanning electron microscopy, x-ray energy dispersive techniques (sem-edx), x-ray diffraction (xrd) and vibrating sample magnetometer (vsm). the adsorbed aptes on the magnetite surface (mnps-aptes) was examined by ftir. the sem image showed that the average particle size is obtained to be about16-51 nm for mnps-aptes. the theophylline loading and release behavior of mnps-aptes were studied and the results showed that up to 70% of the adsorbed drug was released within 6 h. in summary, the mnps-aptes nanocarriers are based on the results, promising for targeted theophylline drug delivery.