• “green synthesis” of benzothiazepine library of indeno analogues and their in vitro antimicrobial activity

    جزئیات بیشتر مقاله
    • تاریخ ارائه: 1392/07/24
    • تاریخ انتشار در تی پی بین: 1392/07/24
    • تعداد بازدید: 866
    • تعداد پرسش و پاسخ ها: 0
    • شماره تماس دبیرخانه رویداد: -
     a novel series of indeno-benzothiazepine derivatives was synthesised via a “green” route. synthesis of these compounds involves the treatment of dinucleophiles such as 2-aminobenzenethiols with α,β-unsaturated ketones in poly(oxyethylene) (poly(ethylene glycol), peg-400) catalysed by acetic acid. the synthone α,β-unsaturated ketones were obtained by claisen-schmidt condensation of indan-1-one with substituted pyrazole-2-carbaldehydes prompted by bleaching earth (ph 12.5) as catalyst and peg-400 as “green” reaction solvent. screening of all the synthesised compounds for antimicrobial activity revealed that most of these compounds exhibited moderate to significant antimicrobial activity.

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