development of albendazole sulfoxide-loaded eudragit microparticles: a potential strategy to improve the drug bioavailability

albendazole sulfoxide (abzso), a broad spectrum anthelmintic drug extensively used in veterinary medicine, exhibits a low and erratic bioavailability due to its poor solubility in biological fluids. the aims of this study were the development, physicochemical characterization, and in vitro release profile evaluation of abzso-loaded eudragit rs po® microparticles (mps) in order to improve the rate of dissolution and the dissolved percentage of the drug in ph 7.4. mps were successfully obtained by the emulsification/solvent evaporation method, achieving entrapment efficiency and process yield of about 60% and mean size of 254 nm. the in vitro release profile study showed that dissolution of abzso followed a pseudo-second order kinetics and mps were able to increase significantly (p < 0.05) the rate of dissolution of abzso compared to the micronized and non-micronized free drug, what could lead to an improvement in bioavailability and, consequently, in the antiparasitic activity.